References

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Neurology, Neuropsychiatry, Psychosomatics

Неврология, нейропсихиатрия, психосоматика

2074-27112310-1342

"IMA-Press", LLC

10.14412/2074-2711-2019-4-4-13

nnp-1202

Research Article

LECTURES

ЛЕКЦИЯ

Antipsychotic-induced tardive dyskinesia as a serious adverse effect in the psychopharmacotherapy of schizophrenia

Антипсихотик-индуцированная тардивная дискинезия как серьезная нежелательная реакция при психофармакотерапии шизофрении

Вайман

Е. Э.

Vaiman

E. E.

vaimanelenadoc@gmail.com

Шнайдер

Н. А.

Shnayder

N. A.

192019, Санкт-Петербург, ул. Бехтерева, 3

3, Bekhterev St., Saint Petersburg 192019

Незнанов

Н. Г.

Neznanov

N. G.

192019, Санкт-Петербург, ул. Бехтерева, 3

3, Bekhterev St., Saint Petersburg 192019

Насырова

Р. Ф.

Nasyrova

R. F.

192019, Санкт-Петербург, ул. Бехтерева, 3

3, Bekhterev St., Saint Petersburg 192019

ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава РоссииРоссияV.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of RussiaRussian Federation

2019

07122019

114413

2019

Вайман Е.Э., Шнайдер Н.А., Незнанов Н.Г., Насырова Р.Ф.

Vaiman E.E., Shnayder N.A., Neznanov N.G., Nasyrova R.F.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://nnp.ima-press.net/nnp/article/view/1202

Schizophrenia is a socially significant disorder with a high prevalence among young and middle-aged people. Movement disorders, or extrapyramidal syndrome, are potentially reversible antipsychotic-induced adverse effects (AEs) that stigmatize patients and worsen quality of life. Tardive dyskinesia (TD) is a neurological AE in the extrapyramidal system, which is accompanied by abnormal involuntary non-rhythmic choreiform or athetoid movements (hyperkinesis) that occur during the long-term use of antipsychotics. The reversible and persistent forms of TD are identified. The article analyzes the prevalence and predictors of TD, as well as the issues of its diagnosis.

Шизофрения – социально значимое расстройство с высокой распространенностью среди лиц молодого и среднего возраста. Нарушения движения, или экстрапирамидный синдром, относятся к потенциально обратимым антипсихотик-индуцированным нежелательным реакциям (НР), которые стигматизируют больных и ухудшают качество жизни. Поздняя (тардивная) дискинезия (ТД) – неврологическая НР со стороны экстрапирамидной системы, сопровождающаяся аномальными непроизвольными неритмичными хореиформными или атетоидными движениями (гиперкинезами), возникающими во время длительного приема антипсихотиков. Выделяют обратимую и персистирующую формы ТД. В статье анализируются распространенность и предикторы ТД, а также вопросы ее диагностики.

антипсихотикишизофрениянежелательная реакцияэкстрапирамидный синдромтардивная дискинезияпредикторыраспространенностьдиагностика

antipsychoticsschizophreniaadverse effectextrapyramidal syndrometardive dyskinesiapredictorsprevalencediagnosis

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The authors declare that there are no conflicts of interest present.