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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2019-3-99-103</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1182</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>Rehabilitation in acute stroke from the point of view of evidence-based medicine: possibilities of drug treatment</article-title><trans-title-group xml:lang="ru"><trans-title>Реабилитация в остром периоде инсульта c точки зрения доказательной медицины: возможности медикаментозного лечения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулеш</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulesh</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>614990, Пермь, ул. Петропавловская, 26;614107, Пермь, ул. Ким, 2</p></bio><bio xml:lang="en"><p>26, Petropavlovskaya St., Perm 614990;2, Kim St., Perm 614107</p></bio><email xlink:type="simple">aleksey.kulesh@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Пермский государственный медицинский университет им. акад. Е.А. Вагнера» Минздрава России;&#13;
ГАУЗ ПК «Городская клиническая больница №4»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Acad. E.A. Vagner Perm State Medical University, Ministry of Health of Russia;&#13;
City Clinical Hospital Four</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>31</day><month>10</month><year>2019</year></pub-date><volume>11</volume><issue>3</issue><fpage>99</fpage><lpage>103</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kulesh A.A., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Кулеш А.А.</copyright-holder><copyright-holder xml:lang="en">Kulesh A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1182">https://nnp.ima-press.net/nnp/article/view/1182</self-uri><abstract><p>The review highlights the fundamental principles of early rehabilitation in ischemic stroke, the benefits and risks of early and very early patient mobilization. It presents data on the efficiency of CIMT-kinesiotherapy and mirror therapy in restoring upper extremity function, as well as procedures for nonpharmacological correction of spatial neglect syndrome. The effect on the rehabilitation of concomitant Alzheimer's disease is analyzed. The areas of pharmacological potentiation of poststroke rehabilitation, the efficiency of cerebrolysin in particular, are considered.</p></abstract><trans-abstract xml:lang="ru"><p>В обзоре освещены фундаментальные основы ранней реабилитации при ишемическом инсульте, преимущества и риски ранней и очень ранней мобилизации пациентов. Представлены данные об эффективности CIMT-кинезиотерапии и зеркальной терапии в восстановлении функции верхней конечности, а также способы немедикаментозной коррекции синдрома пространственного игнорирования. Рассмотрены направления фармакологического потенцирования постинсультной реабилитации, в частности эффективность препарата церебролизин.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инсульт</kwd><kwd>реабилитация</kwd><kwd>мобилизация пациентов</kwd><kwd>CIMT</kwd><kwd>зеркальная терапия</kwd><kwd>неглект</kwd><kwd>церебролизин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stroke</kwd><kwd>rehabilitation</kwd><kwd>patient mobilization</kwd><kwd>CIMT</kwd><kwd>mirror therapy</kwd><kwd>neglect</kwd><kwd>cerebrolysin</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Публикация статьи поддержана ООО «Эвер Нейро Фарма».</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Скворцова ВИ, Шетова ИМ, Какорина ЕП и др. 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