<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2019-3-89-93</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1180</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group></article-categories><title-group><article-title>A case of segmental dystonia with mental/psychic nonmotor disorders</article-title><trans-title-group xml:lang="ru"><trans-title>Случай сегментарной дистонии с психическими недвигательными расстройствами</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Толмачева</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tolmacheva</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра нервных болезней и нейрохирургии,</p><p>119021, Москва, ул. Россолимо, 11, стр. 1</p></bio><bio xml:lang="en"><p>Department of Nervous System Diseases and Neurosurgery,</p><p>11, Rossolimo St., Build. 1, Moscow 119021</p></bio><email xlink:type="simple">vtolmacheva@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романов</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Romanov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научно-исследовательский отдел психосоматической медицины Научно-технологического парка биомедицины, 119435, Москва, ул. Большая Пироговская, 6, стр. 1;</p><p>отдел по изучению пограничной психической патологии и психосоматических расстройств, 115522, Москва, Каширское шоссе, 34</p><p> </p></bio><bio xml:lang="en"><p>Research Department of Psychosomatic Medicine, Science and Technology Park for Biomedicine, 6, Bolshaya Pirogovskaya St., Build. 1, Moscow 119435;</p><p>Department for the Study of Borderline Mental Disease and Psychosomatic Disorders, 34, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гришина</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Grishina</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра нервных болезней и нейрохирургии,</p><p>119021, Москва, ул. Россолимо, 11, стр. 1</p></bio><bio xml:lang="en"><p>Department of Nervous System Diseases and Neurosurgery,</p><p>11, Rossolimo St., Build. 1, Moscow 119021</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)» Минздрава России;&#13;
ФГБНУ «Научный центр психического здоровья»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia;&#13;
Mental Health Research Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>31</day><month>10</month><year>2019</year></pub-date><volume>11</volume><issue>3</issue><fpage>89</fpage><lpage>93</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Tolmacheva V.A., Romanov D.V., Grishina D.A., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Толмачева В.А., Романов Д.В., Гришина Д.А.</copyright-holder><copyright-holder xml:lang="en">Tolmacheva V.A., Romanov D.V., Grishina D.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1180">https://nnp.ima-press.net/nnp/article/view/1180</self-uri><abstract><p>The paper discusses the specific features of clinical presentations in patients with muscle dystonia, the presence of cognitive and mental disorders in dystonia. It presents a clinical case of severe segmental dystonia in a 72-year-old patient with cognitive and mental disorders. The manifestations of dystonia regressed during treatment with botulinum toxin; however, the patient did not report any improvement. An improvement could not be achieved after a psychiatrist's consultation and treatment for mental disorders.</p></abstract><trans-abstract xml:lang="ru"><p>Обсуждаются особенности клинической картины у пациентов, страдающих мышечной дистонией, наличие при дистонии когнитивных и психических расстройств.</p><p>Представлен клинический случай тяжелой формы сегментарной дистонии у пациентки 72 лет, у которой наблюдались когнитивные и психические расстройства. На фоне лечения ботулотоксином проявления дистонии регрессировали, однако пациентка не отметила улучшения состояния. После консультации психиатра и лечения психических нарушений удалось добиться удовлетворительного результата. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>мышечная дистония</kwd><kwd>когнитивные нарушения</kwd><kwd>психические расстройства</kwd><kwd>ботулотоксин</kwd><kwd>ксеомин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>muscle dystonia</kwd><kwd>cognitive impairment</kwd><kwd>mental disorders</kwd><kwd>botulinum toxin</kwd><kwd>xeomin</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Публикация статьи поддержана ООО «Мерц Фарма»</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Albanese A, Bhatia K, Bressman SB, et al. Phenomenology and classification of dystonia: a consensus update. Mov Disord. 2013 Jun 15;28(7):863-73. doi: 10.1002/mds.25475. Epub 2013 May 6.</mixed-citation><mixed-citation xml:lang="en">Albanese A, Bhatia K, Bressman SB, et al. Phenomenology and classification of dystonia: a consensus update. Mov Disord. 2013 Jun 15;28(7):863-73. doi: 10.1002/mds.25475. Epub 2013 May 6.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Evatt ML, Freeman A, Factor S. Adult-onset dystonia. Handb Clin Neurol. 2011;100:481-511. doi: 10.1016/B978-0-444-52014-2.00037-9.</mixed-citation><mixed-citation xml:lang="en">Evatt ML, Freeman A, Factor S. Adult-onset dystonia. Handb Clin Neurol. 2011;100:481-511. doi: 10.1016/B978-0-444-52014-2.00037-9.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Tiderington E, Goodman EM, Rosen AR, et al. How long does it take to diagnose cervical dystonia? J Neurol Sci. 2013 Dec 15;335 (1-2):72-4.</mixed-citation><mixed-citation xml:lang="en">Tiderington E, Goodman EM, Rosen AR, et al. How long does it take to diagnose cervical dystonia? J Neurol Sci. 2013 Dec 15;335 (1-2):72-4.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kuyper DJ, Parra V, Aerts S, et al. The Non-Motor Manifestations of Dystonia: A Systematic Review. Mov Disord. 2011 Jun; 26(7):1206-17. doi: 10.1002/mds.23709. Epub 2011 Apr 11.</mixed-citation><mixed-citation xml:lang="en">Kuyper DJ, Parra V, Aerts S, et al. The Non-Motor Manifestations of Dystonia: A Systematic Review. Mov Disord. 2011 Jun; 26(7):1206-17. doi: 10.1002/mds.23709. Epub 2011 Apr 11.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Stamelou M, Edwards MJ, Hallett M, Bhatia KP. The non-motor syndrome of primary dystonia: clinical and pathophysiological implications. Brain. 2012 Jun;135(Pt 6): 1668-81. doi: 10.1093/brain/awr224. Epub 2011 Sep 20.</mixed-citation><mixed-citation xml:lang="en">Stamelou M, Edwards MJ, Hallett M, Bhatia KP. The non-motor syndrome of primary dystonia: clinical and pathophysiological implications. Brain. 2012 Jun;135(Pt 6): 1668-81. doi: 10.1093/brain/awr224. Epub 2011 Sep 20.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Conte A, Berardelli I, Ferrazzano G, et al. Non-motor symptoms in patients with adultonset focal dystonia: Sensory and psychiatric disturbances. Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S111-4. doi: 10.1016/j.parkreldis.2015.09.001. Epub 2015 Sep 3.</mixed-citation><mixed-citation xml:lang="en">Conte A, Berardelli I, Ferrazzano G, et al. Non-motor symptoms in patients with adultonset focal dystonia: Sensory and psychiatric disturbances. Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S111-4. doi: 10.1016/j.parkreldis.2015.09.001. Epub 2015 Sep 3.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Albanese A, Asmus F, Bhatia KP, et al. EFNS guidelines on diagnosis and treatment of primary dystonias. Eur J Neurol. 2011 Jan;18(1): 5-18. doi: 10.1111/j.1468-1331.2010.03042.x.</mixed-citation><mixed-citation xml:lang="en">Albanese A, Asmus F, Bhatia KP, et al. EFNS guidelines on diagnosis and treatment of primary dystonias. Eur J Neurol. 2011 Jan;18(1): 5-18. doi: 10.1111/j.1468-1331.2010.03042.x.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrazzano G, Berardelli I, Conte A, et al. Motor and non-motor symptoms in blepharospasm: clinical and pathophysiological implications. J Neurol. 2019 Jul 29. doi: 10.1007/s00415-019-09484-w. [Epub ahead of print]</mixed-citation><mixed-citation xml:lang="en">Ferrazzano G, Berardelli I, Conte A, et al. Motor and non-motor symptoms in blepharospasm: clinical and pathophysiological implications. J Neurol. 2019 Jul 29. doi: 10.1007/s00415-019-09484-w. [Epub ahead of print]</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Yang J, Shao N, Song W, et al. Nonmotor symptoms in primary adult-onset cervical dystonia and blepharospasm. Brain Behav. 2016 Dec 18;7(2):e00592. doi: 10.1002/brb3.592. eCollection 2017 Feb.</mixed-citation><mixed-citation xml:lang="en">Yang J, Shao N, Song W, et al. Nonmotor symptoms in primary adult-onset cervical dystonia and blepharospasm. Brain Behav. 2016 Dec 18;7(2):e00592. doi: 10.1002/brb3.592. eCollection 2017 Feb.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor AE, Lang AE, Saint-Cyr JA, et al. Cognitive processes in idiopathic dystonia treated with high-dose anticholinergic therapy: implications for treatment strategies. Clin Neuropharmacol. 1991 Feb;14(1):62-77.</mixed-citation><mixed-citation xml:lang="en">Taylor AE, Lang AE, Saint-Cyr JA, et al. Cognitive processes in idiopathic dystonia treated with high-dose anticholinergic therapy: implications for treatment strategies. Clin Neuropharmacol. 1991 Feb;14(1):62-77.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ostrem JL, Racine CA, Glass GA, et al. Subthalamic nucleus deep brain stimulation in primary cervical dystonia. Neurology. 2011 Mar 8;76(10):870-8. doi: 10.1212/WNL.0b013e31820f2e4f.</mixed-citation><mixed-citation xml:lang="en">Ostrem JL, Racine CA, Glass GA, et al. Subthalamic nucleus deep brain stimulation in primary cervical dystonia. Neurology. 2011 Mar 8;76(10):870-8. doi: 10.1212/WNL.0b013e31820f2e4f.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Foley JA, Vinke RS, Limousin P, Cipolotti L. Relationship of Cognitive Function to Motor Symptoms and Mood Disorders in Patients with Isolated Dystonia. Cogn Behav Neurol. 2017 Mar;30(1):16-22. doi: 10.1097/ WNN.0000000000000117.</mixed-citation><mixed-citation xml:lang="en">Foley JA, Vinke RS, Limousin P, Cipolotti L. Relationship of Cognitive Function to Motor Symptoms and Mood Disorders in Patients with Isolated Dystonia. Cogn Behav Neurol. 2017 Mar;30(1):16-22. doi: 10.1097/ WNN.0000000000000117.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Jahanshahi M, Rowe J, Fuller R. Cognitive executive function in dystonia. J Neurol Neurosurg Psychiatry. 2012 Aug;83(8):814-20. doi: 10.1136/jnnp-2011-301386. Epub 2012 May 23.</mixed-citation><mixed-citation xml:lang="en">Jahanshahi M, Rowe J, Fuller R. Cognitive executive function in dystonia. J Neurol Neurosurg Psychiatry. 2012 Aug;83(8):814-20. doi: 10.1136/jnnp-2011-301386. Epub 2012 May 23.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">van Tricht MJ, Dreissen YE, Cath D, et al. Cognition and psychopathology in myoclonusdystonia. J Neurol Neurosurg Psychiatry. 2012 Aug;83(8):814-20. doi: 10.1136/jnnp2011-301386. Epub 2012 May 23.</mixed-citation><mixed-citation xml:lang="en">van Tricht MJ, Dreissen YE, Cath D, et al. Cognition and psychopathology in myoclonusdystonia. J Neurol Neurosurg Psychiatry. 2012 Aug;83(8):814-20. doi: 10.1136/jnnp2011-301386. Epub 2012 May 23.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Balas M, Peretz C, Badarny S, et al. Neuropsychological profile of DYT1 dystonia. Mov Disord. 2006 Dec;21(12):2073-7.</mixed-citation><mixed-citation xml:lang="en">Balas M, Peretz C, Badarny S, et al. Neuropsychological profile of DYT1 dystonia. Mov Disord. 2006 Dec;21(12):2073-7.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Romano R, Bertolino A, Gigante A, et al. Impaired cognitive functions in adult-onset primary cranial cervical dystonia. Parkinsonism Relat Disord. 2014 Feb;20(2):162-165.</mixed-citation><mixed-citation xml:lang="en">Romano R, Bertolino A, Gigante A, et al. Impaired cognitive functions in adult-onset primary cranial cervical dystonia. Parkinsonism Relat Disord. 2014 Feb;20(2):162-165.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Aleman GG, de Erausquin GA, Micheli F. Cognitive disturbances in primary blepharospasm. Mov Disord. 2009 Oct 30;24(14):2112-20. doi: 10.1002/mds.22736. 18. Greisberg S, McKay D. Neuropsychology of obsessive-compulsive disorder: a review and treatment implications. Clin Psychol Rev. 2003 Feb;23(1):95-117.</mixed-citation><mixed-citation xml:lang="en">Aleman GG, de Erausquin GA, Micheli F. Cognitive disturbances in primary blepharospasm. Mov Disord. 2009 Oct 30;24(14):2112-20. doi: 10.1002/mds.22736. 18. Greisberg S, McKay D. Neuropsychology of obsessive-compulsive disorder: a review and treatment implications. Clin Psychol Rev. 2003 Feb;23(1):95-117.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Vytal KE, Cornwell BR, Letkiewicz AM, et al. The complex interaction between anxiety and cognition: insight from spatial and verbal working memory. Front Hum Neurosci. 2013 Mar 28;7:93. doi: 10.3389/fnhum.2013.00093. eCollection 2013.</mixed-citation><mixed-citation xml:lang="en">Vytal KE, Cornwell BR, Letkiewicz AM, et al. The complex interaction between anxiety and cognition: insight from spatial and verbal working memory. Front Hum Neurosci. 2013 Mar 28;7:93. doi: 10.3389/fnhum.2013.00093. eCollection 2013.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Gundel H, Wolf A, Xidara V, et al. High psychiatric comorbidity in spasmodic torticollis: a controlled study. J Nerv Ment Dis. 2003 Jul; 191(7):465-73.</mixed-citation><mixed-citation xml:lang="en">Gundel H, Wolf A, Xidara V, et al. High psychiatric comorbidity in spasmodic torticollis: a controlled study. J Nerv Ment Dis. 2003 Jul; 191(7):465-73.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Lewis L, Butler A, Jahanshahi M. Depression in focal, segmental and generalized dystonia. J Neurol. 2008 Nov;255(11):1750-5. doi: 10.1007/s00415-008-0020-x. Epub 2008 Nov 13.</mixed-citation><mixed-citation xml:lang="en">Lewis L, Butler A, Jahanshahi M. Depression in focal, segmental and generalized dystonia. J Neurol. 2008 Nov;255(11):1750-5. doi: 10.1007/s00415-008-0020-x. Epub 2008 Nov 13.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Тювина НА, Балабанова ВВ, Гончарова ЕМ. Опыт применения сульпирида при эндогенных депрессивно-ипохондрических расстройствах непсихотического уровня. Неврология, нейропсихиатрия, психосоматика. 2012;4(1):67-71. doi: 10.14412/2074-2711-2012-365</mixed-citation><mixed-citation xml:lang="en">Tyuvina NA, Balabanova VV, Goncharova EM. Experience in using sulpiride in non-psychotic endogenous depressive-hypochondriacal disorders. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2012;4(1):67-71. (In Russ.). doi: 10.14412/2074-2711-2012-365</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Смулевич АБ. Психические расстройства в клинической практике. Москва: МЕДпресс-информ; 2011.</mixed-citation><mixed-citation xml:lang="en">Smulevich AB. Psikhicheskie rasstroistva v klinicheskoi praktike [Mental disorders in clinical practice]. Moscow: MEDpress-inform; 2011.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
