<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2019-3S-89-94</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1139</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>Motor function recovery in patients after ischemic stroke</article-title><trans-title-group xml:lang="ru"><trans-title>Восстановление двигательных функций у пациентов, перенесших ишемический инсульт</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старчина</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Starchina</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра нервных болезней и нейрохирургии лечебного факультета,</p><p>119021, Москва, ул. Россолимо, 11, стр. 1</p></bio><bio xml:lang="en"><p>Department of Nervous System Diseases and Neurosurgery, Faculty of General Medicine, </p><p>11, Rossolimo St., Build. 1, Moscow 119021</p></bio><email xlink:type="simple">yul-starchina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский Университет) Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>24</day><month>06</month><year>2019</year></pub-date><volume>11</volume><issue>3S</issue><issue-title>Спецвыпуск: когнитивные нарушения, цереброваскулярные заболевания</issue-title><fpage>89</fpage><lpage>94</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Starchina Y.A., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Старчина Ю.А.</copyright-holder><copyright-holder xml:lang="en">Starchina Y.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1139">https://nnp.ima-press.net/nnp/article/view/1139</self-uri><abstract><p>Secondary prevention of recurrent stroke and other cardiovascular diseases is of key importance for the management of a patient after ischemic stroke. Medications (antihypertensive, antiplatelet, or anticoagulant drugs and statins) are recommended for use; and a small proportion of patients should undergo surgical treatment (carotid endarterectomy); non-drug treatments (smoking cessation and alcohol abstinence, adherence to the Mediterranean diet, and increased physical activity) are of great importance. Movement disorders are seen in 80% of patients after a stroke and are the leading cause of disability. Therapeutic exercises aimed at training movements in the paretic limbs and at preventing the development of contractures are of utmost importance in post-stroke movement disorders. The use of citicoline to improve motor function recovery is discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Ведущее значение в ведении пациента, перенесшего ишемический инсульт, имеет вторичная профилактика повторного инсульта и других сердечно-сосудистых заболеваний. Рекомендован прием лекарственных препаратов (антигипертензивных, антитромбоцитарных средств или антикоагулянтов, статинов) и, небольшой части пациентов, – хирургическое лечение (каротидная эндартерэктомия), большое значение имеют нелекарственные методы (отказ от курения, злоупотребления алкоголем, приверженность средиземноморской диете, увеличение физической активности). Двигательные нарушения наблюдаются у 80% пациентов после инсульта и являются ведущей причиной инвалидизации. При постинсультных двигательных расстройствах большое значение имеет лечебная гимнастика, направленная на тренировку движений в паретичных конечностях и предотвращение развития контрактур. Обсуждается использование цитиколина с целью улучшения восстановления двигательных функций.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемический инсульт</kwd><kwd>вторичная профилактика инсульта</kwd><kwd>постинсультные двигательные нарушения</kwd><kwd>парез</kwd><kwd>лечебная гимнастика</kwd><kwd>цитиколин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ischemic stroke</kwd><kwd>secondary stroke prevention</kwd><kwd>post-stroke movement disorders</kwd><kwd>paresis</kwd><kwd>therapeutic exercises</kwd><kwd>citicoline</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Feigin V. Global, regional, and national disability-adjusted life years (Dalys) for 315 diseases and injuries and healthy life expectancy (Hale), 1990–2015: a systematic analysis for the global burden of disease study 2015. Lancet. 2016;388:1603-58. doi: 10.1016/S0140-6736(16)31460-X</mixed-citation><mixed-citation xml:lang="en">Feigin V. Global, regional, and national disability-adjusted life years (Dalys) for 315 diseases and injuries and healthy life expectancy (Hale), 1990–2015: a systematic analysis for the global burden of disease study 2015. Lancet. 2016;388:1603-58. doi: 10.1016/S0140-6736(16)31460-X</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА, Хасанова ДР. Ишемический инсульт. Москва: МИА; 2012. 288 с.</mixed-citation><mixed-citation xml:lang="en">Parfenov VA, Khasanova DR. Ishemicheskii insul't [Ischemic stroke]. Moscow: MIA; 2012. 288 p. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">O'Donnell MJ, Chin SL, Rangarajan S, et al. Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. Lancet. 2016;388:761-75. doi: 10.1016/S0140-6736(16)30506-2</mixed-citation><mixed-citation xml:lang="en">O'Donnell MJ, Chin SL, Rangarajan S, et al. Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. Lancet. 2016;388:761-75. doi: 10.1016/S0140-6736(16)30506-2</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Meijer R, Plotnik M, Zwaaftink EG, et al. Markedly impaired bilateral coordination of gait in post-stroke patients: Is this deficit distinct from asymmetry? A cohort study. J Neuroeng Rehabil. 2011;8:23. doi: 10.1186/1743-0003-8-23</mixed-citation><mixed-citation xml:lang="en">Meijer R, Plotnik M, Zwaaftink EG, et al. Markedly impaired bilateral coordination of gait in post-stroke patients: Is this deficit distinct from asymmetry? A cohort study. J Neuroeng Rehabil. 2011;8:23. doi: 10.1186/1743-0003-8-23</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Verdecchia P, Staessen JA, Angeli F, et al. Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial. Lancet. 2009;374:525-33. doi: 10.1016/S0140-6736(09)61340-4</mixed-citation><mixed-citation xml:lang="en">Verdecchia P, Staessen JA, Angeli F, et al. Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial. Lancet. 2009;374:525-33. doi: 10.1016/S0140-6736(09)61340-4</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bath PM, Scutt P, Blackburn DJ, et al. Intensive versus guideline blood pressure and lipid lowering in patients with previous stroke: main results from the pilot 'Prevention of Decline in Cognition after Stroke Trial' (PODCAST) Randomised Controlled Trial. PLoS One. 2017;12(1):e0164608. doi: 10.1371/journal.pone.0164608</mixed-citation><mixed-citation xml:lang="en">Bath PM, Scutt P, Blackburn DJ, et al. Intensive versus guideline blood pressure and lipid lowering in patients with previous stroke: main results from the pilot 'Prevention of Decline in Cognition after Stroke Trial' (PODCAST) Randomised Controlled Trial. PLoS One. 2017;12(1):e0164608. doi: 10.1371/journal.pone.0164608</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rothwell PM, Howard SC, Spence JD, for the Carotide Endarterectomy Trialist`s Collaboration. Relationship between blood pressure and stroke risk in patients with symptomatic carotid occlusive disease. Stroke. 2003;34:2583-92. doi: 10.1161/01.STR.0000094424.38761.56</mixed-citation><mixed-citation xml:lang="en">Rothwell PM, Howard SC, Spence JD, for the Carotide Endarterectomy Trialist`s Collaboration. Relationship between blood pressure and stroke risk in patients with symptomatic carotid occlusive disease. Stroke. 2003;34:2583-92. doi: 10.1161/01.STR.0000094424.38761.56</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324:71-86. doi: 10.1136/ bmj.324.7329.71</mixed-citation><mixed-citation xml:lang="en">Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324:71-86. doi: 10.1136/ bmj.324.7329.71</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Diener HC, Weimar C. Update of secondary stroke prevention. Nephrol Dial Transplant. 2009;24:1718-24. doi: 10.1093/ndt/gfp068</mixed-citation><mixed-citation xml:lang="en">Diener HC, Weimar C. Update of secondary stroke prevention. Nephrol Dial Transplant. 2009;24:1718-24. doi: 10.1093/ndt/gfp068</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">CAPRIE Streering Commitee. A randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischemic events (CAPRIE). Lancet. 1996;348:1329-39. doi: 10.1016/S0140-6736(96)09457-3</mixed-citation><mixed-citation xml:lang="en">CAPRIE Streering Commitee. A randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischemic events (CAPRIE). Lancet. 1996;348:1329-39. doi: 10.1016/S0140-6736(96)09457-3</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Diener HC, Cunha L, Forbes C, et al. European Stroke Prevention Study, 2: dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996;143: 1-13. doi: 10.1016/S0022-510X(96)00308-5</mixed-citation><mixed-citation xml:lang="en">Diener HC, Cunha L, Forbes C, et al. European Stroke Prevention Study, 2: dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996;143: 1-13. doi: 10.1016/S0022-510X(96)00308-5</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC). Eur Heart J. 2016;50(5):e1-e88.</mixed-citation><mixed-citation xml:lang="en">2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC). Eur Heart J. 2016;50(5):e1-e88.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Amarenco P, Labreuche J, Lavalle P, Touboul P-J. Statin in stroke prevention and carotid atherosclerosis: systematic review and meta-analysis. Stroke. 2004;35:2902-9. doi: 10.1161/01.STR.0000147965.52712.fa</mixed-citation><mixed-citation xml:lang="en">Amarenco P, Labreuche J, Lavalle P, Touboul P-J. Statin in stroke prevention and carotid atherosclerosis: systematic review and meta-analysis. Stroke. 2004;35:2902-9. doi: 10.1161/01.STR.0000147965.52712.fa</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Wannamethee SG, Shaper AG, Whincup PH, Walker M. Smoking cessation and the risk of stroke in middle-aged men. JAMA. 1995;274: 155-60. doi: 10.1001/jama.1995.03530020073035</mixed-citation><mixed-citation xml:lang="en">Wannamethee SG, Shaper AG, Whincup PH, Walker M. Smoking cessation and the risk of stroke in middle-aged men. JAMA. 1995;274: 155-60. doi: 10.1001/jama.1995.03530020073035</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes JN. Exercise, cognitive function, and aging. Adv Physiol Educ. 2015;39(2):55-62. doi: 10.1152/advan.00101.2014</mixed-citation><mixed-citation xml:lang="en">Barnes JN. Exercise, cognitive function, and aging. Adv Physiol Educ. 2015;39(2):55-62. doi: 10.1152/advan.00101.2014</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Canevelli M, Lucchini F, Quarata F, et al. Nutrition and Dementia: Evidence for Preventive Approaches? Nutrients. 2016;8(3): 144. doi: 10.3390/nu8030144</mixed-citation><mixed-citation xml:lang="en">Canevelli M, Lucchini F, Quarata F, et al. Nutrition and Dementia: Evidence for Preventive Approaches? Nutrients. 2016;8(3): 144. doi: 10.3390/nu8030144</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Baumgartner R, Oesch L, Sarikaya H. Obesity Paradox and Stroke. Praxis (Bern).2016; 105(14):835-41. doi: 10.1024/1661-8157/a002408</mixed-citation><mixed-citation xml:lang="en">Baumgartner R, Oesch L, Sarikaya H. Obesity Paradox and Stroke. Praxis (Bern).2016; 105(14):835-41. doi: 10.1024/1661-8157/a002408</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Winstein CJ, Stein J, Arena R, et al. Guidelines for adult stroke rehabilitation and recovery. A guideline for healthcare professionals from the American Heart Association/ American Stroke Association. Stroke. 2016; 47:e98-e169. doi: 10.1161/STR.0000000000000098</mixed-citation><mixed-citation xml:lang="en">Winstein CJ, Stein J, Arena R, et al. Guidelines for adult stroke rehabilitation and recovery. A guideline for healthcare professionals from the American Heart Association/ American Stroke Association. Stroke. 2016; 47:e98-e169. doi: 10.1161/STR.0000000000000098</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Pollock A, Baer G, Campbell P, et al. Physical rehabilitation approaches for the recovery of function and mobility following stroke. Cochrane Database System Rev. 2014; (4):Art. No. CD001920. doi: 10.1002/14651858.CD001920.pub3</mixed-citation><mixed-citation xml:lang="en">Pollock A, Baer G, Campbell P, et al. Physical rehabilitation approaches for the recovery of function and mobility following stroke. Cochrane Database System Rev. 2014; (4):Art. No. CD001920. doi: 10.1002/14651858.CD001920.pub3</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Дамулин ИВ, Екушева ЕВ. Процессы нейропластичности после инсульта. Неврология, нейропсихиатрия, психосоматика. 2014;6(3):69-74. doi: 10.14412/2074-2711-2014-3-69-74</mixed-citation><mixed-citation xml:lang="en">Damulin IV, Ekusheva EV. Poststroke neuroplasticity processes. Nevrologiya, Neiropsikhiatriya, Psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2014;6(3):69- 74 (In Russ.). doi: 10.14412/2074-2711-2014-3-69-74</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Mayo NE, Fellows LK, Scott SC, et al. A longitudinal view of apathy and its impact after stroke. Stroke. 2009;40:3299-307. doi: 10.1161/STROKEAHA.109.554410</mixed-citation><mixed-citation xml:lang="en">Mayo NE, Fellows LK, Scott SC, et al. A longitudinal view of apathy and its impact after stroke. Stroke. 2009;40:3299-307. doi: 10.1161/STROKEAHA.109.554410</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Duncan F, Kutlubaev MA, Dennis MS, et al. Fatigue after stroke: a systematic review of associations with impaired physical fitness. Int J Stroke. 2012;7:157-62. doi: 10.1111/j.1747-4949.2011.00741.x</mixed-citation><mixed-citation xml:lang="en">Duncan F, Kutlubaev MA, Dennis MS, et al. Fatigue after stroke: a systematic review of associations with impaired physical fitness. Int J Stroke. 2012;7:157-62. doi: 10.1111/j.1747-4949.2011.00741.x</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Gebruers N, Vanroy C, Truijen S, et al. Monitoring of physical activity after stroke: a systematic review of accelerometry-based measures. Arch Phys Med Rehabil. 2010;91: 288-97. doi: 10.1016/j.apmr.2009.10.025</mixed-citation><mixed-citation xml:lang="en">Gebruers N, Vanroy C, Truijen S, et al. Monitoring of physical activity after stroke: a systematic review of accelerometry-based measures. Arch Phys Med Rehabil. 2010;91: 288-97. doi: 10.1016/j.apmr.2009.10.025</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Lincoln NB, Brinkmann N, Cunningham S, et al. Anxiety and depression after stroke: a 5 year follow-up. Disabil Rehabil. 2013;35:140-5. doi: 10.3109/09638288.2012.691939</mixed-citation><mixed-citation xml:lang="en">Lincoln NB, Brinkmann N, Cunningham S, et al. Anxiety and depression after stroke: a 5 year follow-up. Disabil Rehabil. 2013;35:140-5. doi: 10.3109/09638288.2012.691939</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Вербицкая СВ, Парфенов ВА, Решетников ВА и др. Постинсультные когнитивные нарушения (результаты 5-летнего наблюдения). Неврология, нейропсихиатрия, психосоматика. 2018;10(1):37-42. doi: 10.14412/2074-2711-2018-1-37-42</mixed-citation><mixed-citation xml:lang="en">Verbitskaya SV, Parfenov VA, Reshetnikov VA, et al. Post-stroke cognitive impairment (results of a 5-year follow-up). Nevrologiya, Neiropsikhiatriya, Psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):37-42 (In Russ.). doi: 10.14412/2074-2711-2018-1-37-42</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Gadidi V, Katz-Leurer M, Carmeli E, Bornstein NM. Long-term outcome poststroke: predictors of activity limitation and participation restriction. Arch Phys Med Rehabil. 2011; 92:1802-8. doi: 10.1016/j.apmr.2011.06.014</mixed-citation><mixed-citation xml:lang="en">Gadidi V, Katz-Leurer M, Carmeli E, Bornstein NM. Long-term outcome poststroke: predictors of activity limitation and participation restriction. Arch Phys Med Rehabil. 2011; 92:1802-8. doi: 10.1016/j.apmr.2011.06.014</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kim JH, Sim WS, Won BH. Effectiveness of elastic band-type ankle-foot orthoses on postural control in poststroke elderly patients as determined using combined measurement of the stability index and body weight-bearing ratio. Clin Intervent Aging. 2015;10:1839-47. doi: 10.2147/CIA.S92888</mixed-citation><mixed-citation xml:lang="en">Kim JH, Sim WS, Won BH. Effectiveness of elastic band-type ankle-foot orthoses on postural control in poststroke elderly patients as determined using combined measurement of the stability index and body weight-bearing ratio. Clin Intervent Aging. 2015;10:1839-47. doi: 10.2147/CIA.S92888</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Tiozzo E, Youbi M, Dave K, et al. Aerobic, resistance, and cognitive exercise training poststroke. Stroke. 2015;46:2012-6. doi: 10.1161/STROKEAHA.114.006649</mixed-citation><mixed-citation xml:lang="en">Tiozzo E, Youbi M, Dave K, et al. Aerobic, resistance, and cognitive exercise training poststroke. Stroke. 2015;46:2012-6. doi: 10.1161/STROKEAHA.114.006649</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Francisco GE, Boake C. Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary study. Arch Phys Med Rehabil. 2003;84:1194-9. doi: 10.1016/S0003-9993(03)00134-5</mixed-citation><mixed-citation xml:lang="en">Francisco GE, Boake C. Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary study. Arch Phys Med Rehabil. 2003;84:1194-9. doi: 10.1016/S0003-9993(03)00134-5</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Shaw LC, Price CIM, van Wijck FMJ, et al. Botulinum Toxin for the Upper Limb After Stroke (BoTULS) Trial: Effect on Impairment, Activity Limitation, and Pain. Stroke. 2011; 42:1371-9. doi: 10.1161/STROKEAHA.110.582197</mixed-citation><mixed-citation xml:lang="en">Shaw LC, Price CIM, van Wijck FMJ, et al. Botulinum Toxin for the Upper Limb After Stroke (BoTULS) Trial: Effect on Impairment, Activity Limitation, and Pain. Stroke. 2011; 42:1371-9. doi: 10.1161/STROKEAHA.110.582197</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ward AB, Wissel J, Borg J, et al. Functional goal achievement in post-stroke spasticity patients: the BOTOX® Economic Spasticity Trial (BEST). J Rehabil Med. 2014;46:504-13. doi: 10.2340/16501977-1817</mixed-citation><mixed-citation xml:lang="en">Ward AB, Wissel J, Borg J, et al. Functional goal achievement in post-stroke spasticity patients: the BOTOX® Economic Spasticity Trial (BEST). J Rehabil Med. 2014;46:504-13. doi: 10.2340/16501977-1817</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Толмачева ВА. Постинсультная спастичность, индивидуализированный подход к лечению. Неврология, нейропсихиатрия, психосоматика. 2016;8(4):71-6. doi: 10.14412/2074-2711-2016-4-71-76.</mixed-citation><mixed-citation xml:lang="en">Tolmacheva VA. Poststroke spasticity: An individualized approach to treatment. Nevrologiya, Neiropsikhiatriya, Psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2016;8(4):71-6 (In Russ.). doi: 10.14412/2074-2711-2016-4-71-76.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ding D, Lawson KD, Kolbe-Alexander TL, et al. The economic burden of physical inactivity: a global analysis of major non-communicable diseases. Lancet. 2016;388:1311-24. doi: 10.1016/S0140-6736(16)30383-X</mixed-citation><mixed-citation xml:lang="en">Ding D, Lawson KD, Kolbe-Alexander TL, et al. The economic burden of physical inactivity: a global analysis of major non-communicable diseases. Lancet. 2016;388:1311-24. doi: 10.1016/S0140-6736(16)30383-X</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Rist PM, Capistrant BD, Mayeda ER, et al. Physical activity, but not body mass index, predicts less disability before and after stroke. Neurology. 2017;88:1718-26. doi: 10.1212/WNL.0000000000003888</mixed-citation><mixed-citation xml:lang="en">Rist PM, Capistrant BD, Mayeda ER, et al. Physical activity, but not body mass index, predicts less disability before and after stroke. Neurology. 2017;88:1718-26. doi: 10.1212/WNL.0000000000003888</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Reinholdsson M, Palstam A, Sunnerhagen KS. Prestroke physical activity could influence acute stroke severity (part of PAPSIGOT). Neurology. 2018 Oct 16;91(16): e1461-e1467. Epub 2018 Sep 19.</mixed-citation><mixed-citation xml:lang="en">Reinholdsson M, Palstam A, Sunnerhagen KS. Prestroke physical activity could influence acute stroke severity (part of PAPSIGOT). Neurology. 2018 Oct 16;91(16): e1461-e1467. Epub 2018 Sep 19.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y, Li M, Dong F, et al. Physical exercise-induced protection on ischemic cardiovascular and cerebrovascular diseases. Int J Clin Exp Med. 2015;8:19859-66.</mixed-citation><mixed-citation xml:lang="en">Wang Y, Li M, Dong F, et al. Physical exercise-induced protection on ischemic cardiovascular and cerebrovascular diseases. Int J Clin Exp Med. 2015;8:19859-66.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Middleton LE, Corbett D, Brooks D, et al. Physical activity in the prevention of ischemic stroke and improvement of outcomes: a narrative review. Neurosci Biobehav Rev. 2013;37: 133-7. doi: 10.1016/j.neubiorev.2012.11.011</mixed-citation><mixed-citation xml:lang="en">Middleton LE, Corbett D, Brooks D, et al. Physical activity in the prevention of ischemic stroke and improvement of outcomes: a narrative review. Neurosci Biobehav Rev. 2013;37: 133-7. doi: 10.1016/j.neubiorev.2012.11.011</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Firth N, Barker RN, Hayward KS, et al. Safety and efficacy of recovery-promoting drugs for motor function after stroke: A systematic review of randomised controlled trials. J Rehabil Med. 2019 Feb 25 [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Firth N, Barker RN, Hayward KS, et al. Safety and efficacy of recovery-promoting drugs for motor function after stroke: A systematic review of randomised controlled trials. J Rehabil Med. 2019 Feb 25 [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Bustamante A, Giralt D, Garcia-Bonilla L, et al. Citicoline in pre-clinical animal models of stroke: a meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial. J Neurochem. 2012;123(2):217-25. doi: 10.1111/j.1471-4159.2012.07891.x</mixed-citation><mixed-citation xml:lang="en">Bustamante A, Giralt D, Garcia-Bonilla L, et al. Citicoline in pre-clinical animal models of stroke: a meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial. J Neurochem. 2012;123(2):217-25. doi: 10.1111/j.1471-4159.2012.07891.x</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Gutierrez-Fernandez M, Rodriguez-Frutos B, Fuentes B, et al. CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke. Neurochem Int. 2012;60:310-7. doi: 10.1016/j.neuint.2011.12.015</mixed-citation><mixed-citation xml:lang="en">Gutierrez-Fernandez M, Rodriguez-Frutos B, Fuentes B, et al. CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke. Neurochem Int. 2012;60:310-7. doi: 10.1016/j.neuint.2011.12.015</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Пирадов МА, Сергеев ДВ, Кротенкова МВ. Применение цераксона в остром периоде полушарного ишемического инсульта: клиническая и КТ-перфузионная оценка. Анналы клинической и экспериментальной неврологии. 2012;(3):31-6.</mixed-citation><mixed-citation xml:lang="en">Piradov MA, Sergeev DV, Krotenkova MV. Application of ceraxon in the acute period of hemispheric ischemic stroke: clinical and CT perfusion assessment. Annaly Klinicheskoi i Eksperimental'noi Nevrologii = Annals of Clinical and Experimental Neurology. 2012;(3):31-6 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Secades JJ, Alvarez-Sabin J, Castillo J, et al. Citicoline for acute ischemic stroke: a systematic review and formal meta-analysis of randomized, double-blind, and placebo-controlled trials. J Stroke Cerebrovasc Dis. 2016;25(8): 1984-96. doi: 10.1016/j.jstrokecerebrovasdis.2016.04.010</mixed-citation><mixed-citation xml:lang="en">Secades JJ, Alvarez-Sabin J, Castillo J, et al. Citicoline for acute ischemic stroke: a systematic review and formal meta-analysis of randomized, double-blind, and placebo-controlled trials. J Stroke Cerebrovasc Dis. 2016;25(8): 1984-96. doi: 10.1016/j.jstrokecerebrovasdis.2016.04.010</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Kan T, et al. Drug effect evaluation of CDPcholine in after-effects of stroke by the multicenter double-blind method – Centering on a study by the hemiplegia function recovery 12-grade evaluation method. Jap J Clin Exper Med. 1976;53:3781.</mixed-citation><mixed-citation xml:lang="en">Kan T, et al. Drug effect evaluation of CDPcholine in after-effects of stroke by the multicenter double-blind method – Centering on a study by the hemiplegia function recovery 12-grade evaluation method. Jap J Clin Exper Med. 1976;53:3781.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Hazama T, Hasegawa T, Ueda S, Sakuma A. Evaluation of the effect of CDP-choline on poststroke hemiplegia employing a double-blind controlled trial. Assessed by a new rating scale for recovery in hemiplegia. Int J Neurosci. 1980; 11:211. doi: 10.3109/00207458009147587</mixed-citation><mixed-citation xml:lang="en">Hazama T, Hasegawa T, Ueda S, Sakuma A. Evaluation of the effect of CDP-choline on poststroke hemiplegia employing a double-blind controlled trial. Assessed by a new rating scale for recovery in hemiplegia. Int J Neurosci. 1980; 11:211. doi: 10.3109/00207458009147587</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Ueda S, Hasegawa T, Ando K, et al. Evaluation of the pharmacological effect of CDP-choline injection in post-stroke hemiplegia. Double-blind comparative study using the Hemiplegia Function Test (12-grade evaluation method). Strides Med. 1994;170:297-314.</mixed-citation><mixed-citation xml:lang="en">Ueda S, Hasegawa T, Ando K, et al. Evaluation of the pharmacological effect of CDP-choline injection in post-stroke hemiplegia. Double-blind comparative study using the Hemiplegia Function Test (12-grade evaluation method). Strides Med. 1994;170:297-314.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
