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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2019-2-93-99</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1107</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>Pathogenesis, clinical features, and treatments of depression in Parkinson's disease</article-title><trans-title-group xml:lang="ru"><trans-title>Патогенез, клинические особенности и методы лечения депрессии при болезни Паркинсона</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Милюхина</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Milyukhina</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ирина Валентиновна Милюхина</p><p>197376, Санкт-Петербург, ул. Академика Павлова, 12, </p><p>197089, Санкт-Петербург, ул. Льва Толстого, 6/8  </p></bio><bio xml:lang="en"><p>Irina Valentinovna Milyutina</p><p>12, Academician Pavlov St., Saint Petersburg 197376, 6/8, Lev Tolstoy St., Saint Petersburg 197089</p></bio><email xlink:type="simple">milyukhinaiv@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Институт экспериментальной медицины»;&#13;
ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Experimental Medicine;&#13;
Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>16</day><month>06</month><year>2019</year></pub-date><volume>11</volume><issue>2</issue><fpage>93</fpage><lpage>99</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Milyukhina I.V., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Милюхина И.В.</copyright-holder><copyright-holder xml:lang="en">Milyukhina I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1107">https://nnp.ima-press.net/nnp/article/view/1107</self-uri><abstract><p>Depression is the most common non-motor manifestation of Parkinson's disease (PD), which significantly affects the rate of disease progression and increases the risk of motor complications and dementia. The paper considers the etiology and pathogenesis, cause-and-effect factors of depression in PD, and features of its diagnosis and treatment. Attention is paid to the algorithm for a physician's actions in the detection of depressive disorder in a patient with PD, to the choice of an antidepressant, and to the promising areas of therapy.</p></abstract><trans-abstract xml:lang="ru"><p>Депрессия – самое частое немоторное проявление болезни Паркинсона (БП), существенно влияющее на скорость прогрессирования заболевания и повышающее риск развития двигательных осложнений и деменции. В статье рассматриваются вопросы этиологии и патогенеза, причинно-следственные факторы развития депрессии при БП, особенности диагностики и лечения. Уделено внимание алгоритму действий врача в случае выявления у пациента с БП депрессивного расстройства, выбору антидепрессанта, а также перспективным направлениям терапии.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Паркинсона</kwd><kwd>депрессия</kwd><kwd>антидепрессанты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Parkinson's disease</kwd><kwd>depression</kwd><kwd>antidepressants</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Публикация статьи поддержана ООО «ЛУНДБЕК РУС»</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Epidemiology and etiology of Parkinson's disease: a review of the evidence. Eur J Epidemiol. 2011 Jun;26 Suppl 1:S1-58. doi: 10.1007/s10654-011-9581-6. Epub 2011 May 28.</mixed-citation><mixed-citation xml:lang="en">Epidemiology and etiology of Parkinson's disease: a review of the evidence. 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