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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2009-25</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-11</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACOTHERAPY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАКОТЕРАПИЯ</subject></subj-group></article-categories><title-group><article-title>THERAPY FOR EPILEPSY IN MIDDLE-AGED AND ELDERLY PATIENTS</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности терапии эпилепсии у пациентов среднего и пожилого возраста</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Власов</surname><given-names>П. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Vlasov</surname><given-names>P. N.</given-names></name></name-alternatives><email xlink:type="simple">vpn_neuro@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Andreeva</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">info@ima-press.net</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>МГМСУ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow State Medical University of Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>11</day><month>03</month><year>2009</year></pub-date><volume>1</volume><issue>1</issue><fpage>54</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Vlasov P.N., Andreeva O.V., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Власов П.Н., Андреева О.В.</copyright-holder><copyright-holder xml:lang="en">Vlasov P.N., Andreeva O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/11">https://nnp.ima-press.net/nnp/article/view/11</self-uri><abstract><p>The authors consider the specific features of epilepsy in middle-aged and elderly patients: a preponderance of focal symptomatic and cryptogenic epilepsies, a frequent combination with concomitant mental and somatic diseases, and a relative efficacy of small-dose antiepileptic drugs (AED). Choice of therapy is noted to depend on the form of epilepsy/type of seizures, comorbidity and used medicines. A major focus is on the use of basic AEDs R carbamazepine and valproates. Data on the promise for using depakine chronosphere in middle-aged and elderly patients are given.</p></abstract><trans-abstract xml:lang="ru"><p>Moscow State Medical University of Dentistry The authors consider the specific features of epilepsy in middle-aged and elderly patients: a preponderance of focal symptomatic and cryptogenic epilepsies, a frequent combination with concomitant mental and somatic diseases, and a relative efficacy of small-dose antiepileptic drugs (AED). Choice of therapy is noted to depend on the form of epilepsy/type of seizures, comorbidity and used medicines. A major focus is on the use of basic AEDs Р carbamazepine and valproates. Data on the promise for using depakine chronosphere in middle-aged and elderly patients are given.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>epilepsy</kwd><kwd>antiepileptic drugs</kwd><kwd>carbamazepine</kwd><kwd>valproates</kwd></kwd-group><kwd-group xml:lang="en"><kwd>epilepsy</kwd><kwd>antiepileptic drugs</kwd><kwd>carbamazepine</kwd><kwd>valproates</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">&lt;div&gt;&lt;p&gt;Hauser W.A., Annegers J.F., Kurland L.T. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 1993;34:453-68.&lt;/p&gt;&lt;p&gt;Власов П.Н. Клиническая фармакология лекарственных средств, применяемых при судорожном синдроме. В кн: Клиническая фармакология. Национальное руководство.&lt;/p&gt;&lt;p&gt;Национальный проект «Здоровье». М.: Геотар-Медиа, 2008;882.&lt;/p&gt;&lt;p&gt;Власов П.Н. Алгоритмы диагностики и терапии эпилепсии у взрослых в поликлинических условиях. Фарматека 2006;7:96-104.&lt;/p&gt;&lt;p&gt;Зенков Л.Р. Как улучшить лечение эпилепсии в России. РМЖ 2003;1:8.&lt;/p&gt;&lt;p&gt;Карлов В.А. Стратегия и тактика терапии эпилепсии сегодня. Невропатол и психиатр 2004;8:28-34.&lt;/p&gt;&lt;p&gt;Мухин К.Ю., Петрухин А.С. Эпилептические синдромы. Диагностика и стандарты терапии (справочное руководство). М., 2005;143 с.&lt;/p&gt;&lt;p&gt;Dulac O. and Alvarez J.-Claude.&lt;/p&gt;&lt;p&gt;Bioequivalence of a new sustained-release formulation of sodium valproate, valproate modified-release granules, compared with existing sustained-release formulations after once- , or twice-daily administration. Pharmacotherapy 2005;25(1):35-42. 8.&lt;/p&gt;&lt;p&gt;The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care. Clinical guideline 20.&lt;/p&gt;&lt;p&gt;NICE. London, 2004;73 p.&lt;/p&gt;&lt;p&gt;Glauser T. , Ben-Menachem E., Bourgeois B. et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006;47:1094-120.&lt;/p&gt;&lt;p&gt;Karceski S., Morrell M., Carpenter D. Treatment of epilepsy in adults: expert opinion. Epilepsy&amp;amp;Behavior 2005;1-64.&lt;/p&gt;&lt;p&gt;Sillanpaa M. Carbamazepine. The treatment of epilepsy. Second edition. 2004. Shorvon S., Perucca E., Fish D. et al. Blackwell science 345-57.&lt;/p&gt;&lt;p&gt;Власов П.Н. Дифференциальная диагностика основных пароксизмальных состояний в практике невролога и терапевта. Фарматека 2008;5:91-4.&lt;/p&gt;&lt;/div&gt;&lt;br /&gt;</mixed-citation><mixed-citation xml:lang="en">&lt;div&gt;&lt;p&gt;Hauser W.A., Annegers J.F., Kurland L.T. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 1993;34:453-68.&lt;/p&gt;&lt;p&gt;Власов П.Н. Клиническая фармакология лекарственных средств, применяемых при судорожном синдроме. В кн: Клиническая фармакология. Национальное руководство.&lt;/p&gt;&lt;p&gt;Национальный проект «Здоровье». М.: Геотар-Медиа, 2008;882.&lt;/p&gt;&lt;p&gt;Власов П.Н. Алгоритмы диагностики и терапии эпилепсии у взрослых в поликлинических условиях. Фарматека 2006;7:96-104.&lt;/p&gt;&lt;p&gt;Зенков Л.Р. Как улучшить лечение эпилепсии в России. РМЖ 2003;1:8.&lt;/p&gt;&lt;p&gt;Карлов В.А. Стратегия и тактика терапии эпилепсии сегодня. Невропатол и психиатр 2004;8:28-34.&lt;/p&gt;&lt;p&gt;Мухин К.Ю., Петрухин А.С. Эпилептические синдромы. Диагностика и стандарты терапии (справочное руководство). М., 2005;143 с.&lt;/p&gt;&lt;p&gt;Dulac O. and Alvarez J.-Claude.&lt;/p&gt;&lt;p&gt;Bioequivalence of a new sustained-release formulation of sodium valproate, valproate modified-release granules, compared with existing sustained-release formulations after once- , or twice-daily administration. Pharmacotherapy 2005;25(1):35-42. 8.&lt;/p&gt;&lt;p&gt;The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care. Clinical guideline 20.&lt;/p&gt;&lt;p&gt;NICE. London, 2004;73 p.&lt;/p&gt;&lt;p&gt;Glauser T. , Ben-Menachem E., Bourgeois B. et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006;47:1094-120.&lt;/p&gt;&lt;p&gt;Karceski S., Morrell M., Carpenter D. Treatment of epilepsy in adults: expert opinion. Epilepsy&amp;amp;Behavior 2005;1-64.&lt;/p&gt;&lt;p&gt;Sillanpaa M. Carbamazepine. The treatment of epilepsy. Second edition. 2004. Shorvon S., Perucca E., Fish D. et al. Blackwell science 345-57.&lt;/p&gt;&lt;p&gt;Власов П.Н. Дифференциальная диагностика основных пароксизмальных состояний в практике невролога и терапевта. Фарматека 2008;5:91-4.&lt;/p&gt;&lt;/div&gt;&lt;br /&gt;</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
