nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2019-2-37-41nnp-1097Research ArticleORIGINAL INVESTIGATIONSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИAssociation of DRD2/ANKK1 Taq1A polymorphism with depression in an open 45–64 year-old male population (international epidemiological HAPIEE and WHO MONICA programs)Ассоциация полиморфизма гена DRD2/ANKK1 Taq1A с депрессией в открытой популяции мужчин 45–64 лет (международные эпидемиологические программы HAPIEE и ВОЗ MONICA)ГафаровВ. В.GafarovV. V.

Валерий Васильевич Гафаров

Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеваний

630089, Новосибирск, ул. Б. Богаткова, 175/1 

Valery Vasilyevich Gafarov

Collaborative Laboratory of Cardiovascular Diseases Epidemiology

175/1, B. Bogatkov St., Novosibirsk 630089

valery.gafarov@gmail.comГромоваЕ. А.GromovaE. A.

Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеваний

630089, Новосибирск, ул. Б. Богаткова, 175/1 

Collaborative Laboratory of Cardiovascular Diseases Epidemiology

175/1, B. Bogatkov St., Novosibirsk 630089

ПановД. О.PanovD. O.

Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеваний

630089, Новосибирск, ул. Б. Богаткова, 175/1 

Collaborative Laboratory of Cardiovascular Diseases Epidemiology

175/1, B. Bogatkov St., Novosibirsk 630089

МаксимовВ. Н.MaximovV. N.

630089, Новосибирск, ул. Б. Богаткова, 175/1 

175/1, B. Bogatkov St., Novosibirsk 630089

ГагулинИ. В.GagulinI. V.

Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеваний

630089, Новосибирск, ул. Б. Богаткова, 175/1 

Collaborative Laboratory of Cardiovascular Diseases Epidemiology

175/1, B. Bogatkov St., Novosibirsk 630089

ГафароваА. В.GafarovaA. V.

Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеваний

630089, Новосибирск, ул. Б. Богаткова, 175/1 

Collaborative Laboratory of Cardiovascular Diseases Epidemiology

175/1, B. Bogatkov St., Novosibirsk 630089

Научно-исследовательский институт терапии и профилактической медицины – филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»РоссияResearch Institute of Internal and Preventive Medicine, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of SciencesRussian Federation2019150620191123741Copyright © Gafarov V.V., Gromova E.A., Panov D.O., Maximov V.N., Gagulin I.V., Gafarova A.V., 20192019Гафаров В.В., Громова Е.А., Панов Д.О., Максимов В.Н., Гагулин И.В., Гафарова А.В.Gafarov V.V., Gromova E.A., Panov D.O., Maximov V.N., Gagulin I.V., Gafarova A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1097Objective

Objective: to study the association of DRD2/ANKK1 Taq1A polymorphism with depression in an open 45–64-year-old male population from Novosibirsk.

Patients and methods

Patients and methods. A representative sample of an open 45–64-year-old male population (n=781) was surveyed within Screening IV of the international HAPIEE program and the WHO MONICA-psychosocial program in 2003–2005. All the study participants filled out the WHO MONICA-psychosocial Program Depression Scale. The DRD2/ANKK1 Taq1A C32806T (rs 1800497) polymorphism was genotyped using the published methods within the budgeting topic. The Pearson's chi-square (2) test was applied to test the statistical significance of differences between the groups. Significance in all types of analysis was taken at p ≤0.05.

Results and discussion

Results and discussion. The prevalence of depression in the open 45–64-year-old male population was 36.3%: 13.5% of the examinees had severe depression (SD) and 22.8% had moderate depression (MD). A comparative intergroup analysis showed that the odds ratio (OR) for the incidence of SD was 3.86 times higher in the T/C genotype carriers than in the C/C genotype ones, who, on the contrary, had no depression; the OR for the incidence of SD was also 3.28 times higher in the T/C genotype carriers, while MD was more common in the homozygous C/C genotype carriers. The OR for the incidence of SD was 2.63 times higher in the DRD2 T allele carriers than in the C allele carriers who did not suffer from depression in most cases.

Conclusion

Conclusion. A significant association was established between the carriage of Taq1A (T allele) and depression in 45–64-year-old males.

Цель исследования – изучение ассоциации полиморфизма гена DRD2/ANKK1 Taq1A с депрессией в открытой популяции мужчин 45–64 лет Новосибирска.

Пациенты и методы

Пациенты и методы. В рамках IV скрининга международной программы HAPIEE, программы ВОЗ MONICA-psychosocial в 2003–2005 гг. была обследована репрезентативная выборка мужчин в возрасте 45–64 лет (n=781). Все участники исследования заполняли шкалу депрессии программы ВОЗ MONICA-psychosocial. Было проведено генотипирование полиморфизма гена DRD2/ANKK1 Taq1A C32806T (rs 1800497) по опубликованным методикам в рамках бюджетной темы. Для проверки статистической значимости различий между группами использовали критерий 2 Пирсона. Значимость во всех видах анализа была принята при уровне p≤0,05.

Результаты и обсуждение

Результаты и обсуждение. Распространенность депрессии в открытой популяции мужчин 45–64 составила 36,3%: у 13,5% обследованных был высокий уровень депрессии (ВД) и у 22,8% – средний (СД). Сравнительный межгрупповой анализ показал, что относительный шанс (ОШ) возникновения ВД был выше в 3,86 раза у носителей генотипа T/C, чем у носителей генотипа С/С, у которых, напротив, депрессии не было; также ОШ возникновения ВД был в 3,28 раза выше у носителей генотипа T/C, в то время как СД чаще наблюдался у носителей гомозиготного генотипа С/С. У носителей аллеля T гена DRD2 ОШ возникновения ВД был выше в 2,63 раза, чем у носителей аллеля C, которые в большинстве случаев депрессией не страдали.

Заключение

Заключение. Установлена достоверная связь между носительством гена Taq1A (аллель T) и депрессией у мужчин 45–64 лет

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The authors declare that there are no conflicts of interest present.