nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2019-1-117-124nnp-1056Research ArticleREVIEWSОБЗОРЫMolecular mechanisms of myoprotective action of chondroitin sulfate and glucosamine sulfate in sarcopeniaМолекулярные механизмы миопротективного действия хондроитина сульфата и глюкозамина сульфата при саркопенииГромоваО. А.GromovaO. A.

Ольга Алексеевна Громова

119333, Москва, Вавилова, 44, корп. 2, 119991, Москва, Ленинские горы, 1

Olga Alekseevna Gromova

Big Data Storage and Analysis CenterM.V. Lomonosov Moscow State University

44, Vavilov St., Build. 2, Moscow 119333, 1, Leninskie Gory, Moscow 119991

unesco.gromova@gmail.comТоршинИ. Ю.TorshinI. Yu.

119333, Москва, Вавилова, 44, корп. 2, 119991, Москва, Ленинские горы, 1

Big Data Storage and Analysis CenterM.V. Lomonosov Moscow State University

44, Vavilov St., Build. 2, Moscow 119333, 1, Leninskie Gory, Moscow 119991

ЛилаА. М.LilaA. M.

Кафедра факультетской терапии им. акад. А.И. Нестерова 

115522, Москва, Каширское шоссе, 34А

 

34A, Kashirskoe Shosse, Moscow 115522

ШостакН. А.ShostakN. A.

Кафедра факультетской терапии им. акад. А.И. Нестерова 

117997, Москва, ул. Островитянова, 1

A.I. Nesterov Department of Intermediate-Level Therapy

1, Ostrovityanov St., Moscow 117997

РудаковК. В.RudakovK. V.

119333, Москва, Вавилова, 44, корп. 2, 119991, Москва, Ленинские горы, 1

Big Data Storage and Analysis CenterM.V. Lomonosov Moscow State University

44, Vavilov St., Build. 2, Moscow 119333, 1, Leninskie Gory, Moscow 119991

Федеральный исследовательский центр «Информатика и управление» Российской академии наук; Центр хранения и анализа больших данных ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияFederal Research Center “Informatics and Management”, Russian Academy of Sciences; M.V. Lomonosov Moscow State UniversityRussian FederationФедеральный исследовательский центр «Информатика и управление» Российской академии наук;РоссияFederal Research Center “Informatics and Management”, Russian Academy of Sciences; M.V. Lomonosov Moscow State UniversityRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияN.I. Pirogov Russian National Research Medical UniversityRussian Federation201906032019111117124Copyright © Gromova O.A., Torshin I.Y., Lila A.M., Shostak N.A., Rudakov K.V., 20192019Громова О.А., Торшин И.Ю., Лила А.М., Шостак Н.А., Рудаков К.В.Gromova O.A., Torshin I.Y., Lila A.M., Shostak N.A., Rudakov K.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1056

The pathogenesis of sarcopenia is complex and associated with impaired muscle protein synthesis, enhanced myocyte apoptosis, increased systemic inflammation, etc. The authors have carried out a systems analysis of 31 992 articles on sarcopenia, which are presented in the biomedical database PubMed, to clarify a set of comorbid interactions of sarcopenia with osteoarthritis, osteoporosis, and other diseases and to justify the use of chondroitin sulfate (CS) and glucosamine sulfate (GS) in these patients. The molecular mechanisms of action of CS and GS on the pathophysiology of sarcopenia have been formulated. By interacting with CD44 receptor, the CS/GS molecules inactivate the proinflammatory factor NF-kB, the activity of which is enhanced in muscle atrophy. In addition, CS/GS provides building material for the regeneration of connective tissue around the myocytes. Thus, the highly purified drugs CS /GS should be used to slow sarcopenia progression.

Патогенез саркопении сложен и связан с нарушением синтеза мышечного белка, усилением апоптоза миоцитов, повышенным системным воспалением и др. Проведен систематический анализ 31 992 статей, посвященных саркопении, представленных в базе данных биомедицинских публикаций PubMed, для уточнения комплекса коморбидных взаимодействий саркопении с остеоартритом, остеопорозом и другими заболеваниями и обоснования назначения препаратов хондроитина сульфата (ХС) и глюкозамина сульфата (ГС) таким пациентам. Сформулированы молекулярные механизмы влияния ХС и ГС на патофизиологию саркопении. Взаимодействуя с рецептором CD44, молекулы ХС/ГС инактивируют провоспалительный фактор NF-kB, активность которого повышена при атрофии мышц. Кроме того, ХС/ГС представляют собой «строительный материал» для регенерации соединительной ткани вокруг миоцитов. Таким образом, высокоочищенные препараты ХС/ГС целесообразно использовать для замедления прогрессирования саркопении.

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The authors declare that there are no conflicts of interest present.