nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2019-1-103-108nnp-1054Research ArticleREVIEWSОБЗОРЫCognitive impairment in primary hyperparathyroidismКогнитивные нарушения при первичном гиперпаратиреозеМокрышеваН. Г.MokryshevaN. G.

117036, Москва, ул. Дм. Ульянова, 11

11, Dm. Ulyanov St., Moscow 117036

КрупиноваЮ. А.KrupinovaYu. A.

117036, Москва, ул. Дм. Ульянова, 11

11, Dm. Ulyanov St., Moscow 117036

БибикЕ. Е.BibikE. E.

Екатерина Евгеньевна Бибик

117036, Москва, ул. Дм. Ульянова, 11

 

Ekaterina Evgenyevna Bibik

11, Dm. Ulyanov St., Moscow 117036

bibikaterina@mail.ruМельниченкоГ. А.MelnichenkoG. A.

117036, Москва, ул. Дм. Ульянова, 11

11, Dm. Ulyanov St., Moscow 117036

ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава РоссииРоссияNational Medical Research Center for Endocrinology, Ministry of Health of RussiaRussian Federation201906032019111103108Copyright © Mokrysheva N.G., Krupinova Y.A., Bibik E.E., Melnichenko G.A., 20192019Мокрышева Н.Г., Крупинова Ю.А., Бибик Е.Е., Мельниченко Г.А.Mokrysheva N.G., Krupinova Y.A., Bibik E.E., Melnichenko G.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1054

Cognitive impairment (CI) is a nonclassical manifestation of primary hyperparathyroidism associated with impaired calcium and phosphorus metabolism. The pathophysiological mechanisms of cognitive dysfunction in this endocrine disease have not been fully elucidated. Nonetheless, studies have demonstrated neuropsychological improvements and better quality of life in patients who have achieved normocalcemia with reduced parathyroid hormone levels after surgical treatment for hyperparathyroidism. Further large-scale controlled studies are needed to determine the possibility of using neuropsychiatric complications as indications for parathyroidectomy.

Когнитивные нарушения (КН) являются неклассическим проявлением первичного гиперпаратиреоза, связанного с нарушением фосфорно-кальциевого обмена. Патофизиологические механизмы когнитивной дисфункции при этом эндокринном заболевании до конца не выяснены. Тем не менее продемонстрировано улучшение нейропсихологического состояния и качества жизни пациентов на фоне достижения нормокальциемии и снижения уровня паратгормона после хирургического лечения гиперпаратиреоза. Для определения возможности использования психоневрологических осложнений в качестве показаний к паратиреоидэктомии необходимы дальнейшие крупные контролируемые исследования.

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The authors declare that there are no conflicts of interest present.