nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2019-1-89-95nnp-1052Research ArticleREVIEWSОБЗОРЫTapering (deprescribing) of benzodiazepine tranquilizersПостепенная отмена (депрескрайбинг) бензодиазепиновых транквилизаторовСычевд. А.SychevD. A.ЖучковА. В.ZhuchkovA. V.

Антон Владимирович Жучков

125993, Москва, ул. Баррикадная, 2/1, стр. 1

Anton Vladimirovich Zhuchkov

2/1, Barrikadnaya St., Build. 1, Moscow 125993

anton.zhuchkov93@gmail.comТерещенкоО. В.TereshchenkoO. V.

117997, Москва, ул. Островитянова, 1

Иващенкод. В.IvashchenkoD. V.ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияRussian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaRussian FederationФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Federation2019060320191118995Copyright © Sychev D.A., Zhuchkov A.V., Tereshchenko O.V., Ivashchenko D.V., 20192019Сычев д.А., Жучков А.В., Терещенко О.В., Иващенко д.В.Sychev D.A., Zhuchkov A.V., Tereshchenko O.V., Ivashchenko D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1052

Deprescribing is the opposite of prescribing drugs, the purpose of which is to improve quality of life and reduce the risk of adverse drug reactions. The paper considers the process of deprescribing benzodiazepines. It analyzes relevant studies on this problem, as well as recommendations to help decide whether it is a need for deprescribing and how to accurately do this. There are also the results of original investigations demonstrating the tapering of benzodiazepine tranquilizers: comparison of simple tampering, use of psychotherapy, or replacement pharmacotherapy. The use of a deprescribing algorithm is the safest way to discontinue benzodiazepines in patients who do not have serious indications for their long-term use.

Депрескрайбинг – процесс, обратный назначению лекарств, целью которого являются улучшение качества жизни пациента и снижение риска развития нежелательных лекарственных реакций. В статье рассмотрен процесс депрескрайбинга бензодиазепинов. Проанализированы актуальные исследования, посвященные данной проблеме, и рекомендации, помогающие принять решение о необходимости депрескрайбинга и правильном его проведении. Также представлены результаты оригинальных исследований, демонстрирующих постепенную отмену бензодиазепиновых транквилизаторов: сравнение простой отмены, применения психотерапии или замещающей фармакотерапии. Использование алгоритма депрескрайбинга – наиболее безопасный способ отмены бензодиазепинов у пациентов, у которых нет серьезных показаний для их длительного приема.

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The authors declare that there are no conflicts of interest present.