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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2019-1-12-20</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1041</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ</subject></subj-group></article-categories><title-group><article-title>Social support and stroke risk: an epidemiological study of a population aged 25–64 years in Russia/Siberia (the WHO MONICA-psychosocial program)</article-title><trans-title-group xml:lang="ru"><trans-title>Социальная поддержка и риск инсульта: эпидемиологическое исследование населения в возрасте 25–64 лет в России/Сибири (программа ВОЗ MONICA-psychosocial)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гафарова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gafarova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>630089, Новосибирск, ул. Б. Богаткова, 175/1</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Громова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gromova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>630089, Новосибирск, ул. Б. Богаткова, 175/1</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панов</surname><given-names>Д. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Panov</surname><given-names>D. О.</given-names></name></name-alternatives><bio xml:lang="ru"><p>630089, Новосибирск, ул. Б. Богаткова, 175/1</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гагулин</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gagulin</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>630089, Новосибирск, ул. Б. Богаткова, 175/1</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крымов</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krymov</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>630089, Новосибирск, ул. Б. Богаткова, 175/1</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гафаров</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gafarov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Валерий Васильевич Гафаров</p><p>630089, Новосибирск, ул. Б. Богаткова, 175/1</p></bio><bio xml:lang="en"><p>Valery Vasilyevich Gafarov</p><p>175/1, B. Bogatkov St., Novosibirsk 630089</p></bio><email xlink:type="simple">valery.gafarov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт терапии и профилактической медицины – филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»;&#13;
Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеваний</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>04</day><month>03</month><year>2019</year></pub-date><volume>11</volume><issue>1</issue><fpage>12</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Gafarova A.V., Gromova E.A., Panov D.О., Gagulin I.V., Krymov E.A., Gafarov V.V., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Гафарова А.В., Громова Е.А., Панов Д.О., Гагулин И.В., Крымов Э.А., Гафаров В.В.</copyright-holder><copyright-holder xml:lang="en">Gafarova A.V., Gromova E.A., Panov D.О., Gagulin I.V., Krymov E.A., Gafarov V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1041">https://nnp.ima-press.net/nnp/article/view/1041</self-uri><abstract><sec><title>Objective</title><p>Objective: to determine the impact of social support on the risk of stroke in an open population aged 25–64 years in Russia/Siberia.</p></sec><sec><title>Patients and methods</title><p>Patients and methods. A random representative sample of a Novosibirsk population aged 25–64 years (657 men; mean age, 44.3±0.4 years; response rate, 82.1%; 689 women; mean age, 45.4±0.4 years; response rate, 72.5%) was examined within Screening III of the WHO MONICApsychological program. The screening program included: registration of sociodemographic data and determination of social support (the index of close contacts (ICC) and the social network index (SNI). The prospective follow-up study period was 16 years. The study identified the following end-point: new-onset stroke cases.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. The open population aged 25–64 years showed a low ICC in 62% of men and in 56.8% of women (χ2=22.603; df=2; p=0.0001) and a low SNI in 43.5% of men and in 33.9% of women (χ2=21.546; df=2; p=0.0001). During a 16-year follow-up, the risk of stroke in the people with a low ICC was 3.5 times higher for men (95% confidence interval (CI), 1.42–7.69; p&lt;0.05), and that was 3.6 times higher for women (95% CI, 1.5–8.7; p&lt;0.01). Over the same follow-up period, the risk of stroke in the patients having a low SNI was 3.4-fold higher for men (95% CI 1.28–5.46, p&lt;0.001) and 2.3-fold higher for women (95% CI 1.18–4.49, p&lt;0.05). Application of a multivariate model revealed an increase in the risk of stroke in people with a low level of social support: in men with an unfavorable family status, manual labor and in women with a low level of education.</p></sec><sec><title>Conclusion</title><p>Conclusion. Social support is a protective risk factor for stroke in both men and women.</p></sec></abstract><trans-abstract xml:lang="ru"><p>Цель исследования – определить влияние социальной поддержки на риск возникновения инсульта в открытой популяции населения 25–64 лет в России/Сибири.</p><sec><title>Пациенты и методы</title><p>Пациенты и методы. В рамках III скрининга программы ВОЗ MONICA-psychosocial в 1994 г. обследована случайная репрезентативная выборка населения Новосибирска 25–64 лет (657 мужчин, 44,3±0,4 года, отклик –82,1%; 689 женщин, 45,4±0,4 года, отклик – 72,5%). Программа скрининга включала: регистрацию социально-демографических данных, определение социальной поддержки (ICC – индекс близких контактов, SNI – индекс социальных связей). Срок проспективного наблюдения за участниками составил 16 лет. В исследовании выделена следующая конечная точка: впервые возникшие случаи инсульта.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. В открытой популяции населения 25–64 лет низкий ICC был у 62% мужчин и 56,8% женщин (χ2=22,603, df=2, р=0,0001); низкий SNI – у 43,5% мужчин и 33,9% женщин (χ2=21,546, df=2, р=0,0001). За 16 лет наблюдения при низком ICC риск возникновения инсульта у мужчин был выше в 3,5 раза (95% доверительный интервал, ДИ 1,42–7,69; p&lt;0,05), а у женщин – в 3,6 раза (95% ДИ 1,5–8,7; p&lt;0,01). На фоне низкого SNI в течение 16 лет наблюдения риск развития инсульта у мужчин составил 3,4 (95% ДИ 1,28–5,46; p&lt;0,001), у женщин – 2,3 (95% ДИ 1,18–4,49; p&lt;0,05). При использовании многофакторной модели установлено увеличение риска инсульта у лиц с низким уровнем социальной поддержки: у мужчин с неблагополучным семейным положением, занимающихся физическим трудом, и у женщин с низким уровнем образования.</p></sec><sec><title>Заключение</title><p>Заключение. Социальная поддержка является протективным фактором риска развития инсульта как у мужчин, так и у женщин.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>популяция</kwd><kwd>мужчины</kwd><kwd>женщины</kwd><kwd>социальная поддержка</kwd><kwd>инсульт</kwd><kwd>риск инсульта</kwd></kwd-group><kwd-group xml:lang="en"><kwd>population</kwd><kwd>men</kwd><kwd>women</kwd><kwd>social support</kwd><kwd>stroke</kwd><kwd>stroke risk</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics-2014 update: a report from the American Heart Association. Circulation. 2014 Jan 21;129(3):e28-e292. doi: 10.1161/01.cir.0000441139.02102.80. Epub 2013 Dec 18.</mixed-citation><mixed-citation xml:lang="en">Go AS, Mozaffarian D, Roger VL, et al. 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