References

nnp

Neurology, Neuropsychiatry, Psychosomatics

Неврология, нейропсихиатрия, психосоматика

2074-27112310-1342

"IMA-Press", LLC

10.14412/2074-2711-2019-1-4-11

nnp-1040

Research Article

LECTURES

ЛЕКЦИЯ

Primary progressive aphasia

Первичная прогрессирующая афазия

Михайлов

В. А.

Mikhailov

V. A.

193019, Санкт-Петербург, ул. Бехтерева, 3

Коцюбинская

Ю. В.

Kotsiubinskaya

Yu. V.

Юлия Вадимовна Коцюбинская

193019, Санкт-Петербург, ул. Бехтерева, 3

Julia Vadimovna Kotsiubinskaya

Saint Petersburg

juliak66@rambler.ru

Сафонова

Н. Ю.

Safonova

N. Yu.

Ананьева

Н. И.

Ananieva

N. I.

Стулов

И. К.

Stulov

I. K.

ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава РоссииРоссияBekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of RussiaRussian Federation

2019

04032019

111411

2019

Михайлов В.А., Коцюбинская Ю.В., Сафонова Н.Ю., Ананьева Н.И., Стулов И.К.

Mikhailov V.A., Kotsiubinskaya Y.V., Safonova N.Y., Ananieva N.I., Stulov I.K.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://nnp.ima-press.net/nnp/article/view/1040

Primary progressive aphasia (PPA) is a heterogeneous group of neurodegenerative diseases related to focal degenerations of the brain and mainly manifested by a gradual loss of speech functions. This symptom is characterized by specific speech disorders. The article presents the etiopathogenic features of PPA, systematizes the clinical criteria for its diagnosis, and describes the modern neuroimaging characteristics of different types of PPA. The proposed PPA severity point scale allows clinicians to record the very early manifestations of aphasia. Modified scales, such as the Frontal Behavioral Inventory (FBI-mod) and the Clinical Dementia Rating (CDR), are also important for specifying the type of PPA.

Первичная прогрессирующая афазия (ППА) – гетерогенная группа нейродегенеративных заболеваний, относящихся к фокальным дегенерациям головного мозга и преимущественно проявляющихся постепенной утратой речевых функций. Для данного симптома характерны специфические речевые нарушения. Представлены этиопатогенические особенности ППА, систематизированы клинические критерии ее диагностики, описаны современные нейровизуализационные характеристики разных видов ППА. Предлагаемая балльная шкала тяжести симптомов ППА позволяет фиксировать уже начальные проявления афазии. Важное значение имеют также модифицированные шкалы для уточнения формы ППА, такие как Frontal Behavioral Inventory (FBI-mod) и Clinical Dementia Rating (CDR).

синдром первичной прогрессирующей афазиидеменциятау-протеинбета-амилоидмагнитно-резонансная томография с морфометрией

primary progressive aphasiadementiatau proteinbeta amyloidmagnetic resonance imaging with morphometry

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The authors declare that there are no conflicts of interest present.