nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2018-4-101-110nnp-1004Research ArticleREVIEWSОБЗОРЫApproaches to therapy for depressions in neurology: prospects for the use of agomelatineПодходы к терапии депрессии в неврологии (перспективы применения агомелатина)РомановД. В.RomanovD. V.

Кафедра психиатрии и психосоматики лечебного факультета.

119991, Москва, ул. Трубецкая, 8, стр. 2; 115552, Москва, Каширское шоссе, 34

Department of Psychiatry and Psychosomatics, Faculty of General Medicine.

8, Trubetskaya St., Build. 2, Moscow 119991; 34, Kashirskoe Shosse, Moscow 115552

ВолельБ. А.VolelB. A.

Беатриса Альбертовна Волель - кафедра психиатрии и психосоматики лечебного факультета.

119991, Москва, ул. Трубецкая, 8, стр. 2; 115552, Москва, Каширское шоссе, 34

Beatrice Albertovna Volel - Department of Psychiatry and Psychosomatics, Faculty of General Medicine.

8, Trubetskaya St., Build. 2, Moscow 119991; 34, Kashirskoe Shosse, Moscow 115552

beatrice.volel@gmail.comПетелинД. С.PetelinD. S.

Кафедра психиатрии и психосоматики лечебного факультета.

119991, Москва, ул. Трубецкая, 8, стр. 2; 115552, Москва, Каширское шоссе, 34

Department of Psychiatry and Psychosomatics, Faculty of General Medicine.

8, Trubetskaya St., Build. 2, Moscow 119991; 34, Kashirskoe Shosse, Moscow 115552

ФГАОУВО «Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)» Минздрава России; ФГБНУНаучный центр психического здоровьяРоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; Mental Health Research CenterRussian Federation201815122018104101110Copyright © Romanov D.V., Volel B.A., Petelin D.S., 20182018Романов Д.В., Волель Б.А., Петелин Д.С.Romanov D.V., Volel B.A., Petelin D.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1004

This review provides information on prospects for using the antidepressant agomelatine in neurological practice. The drug has a unique receptor profile, being a melatonin receptor type 1 and 2 agonist and a serotonin receptor subtype 2C antagonist. Due to this and in addition to antidepressant action, the drug has a number of other effects, such as analgesic, anti-apathetic, anti-asthenic, procognitive, anxiolytic, and sleep-normalizing ones, which are of great importance in the treatment of neurological diseases. There are clinical and experimental data that prove the high efficiency and safety of agomelatin in the follow-up of patients with post-stroke depression, Parkinson’s disease, Alzheimer’s disease, Pick’s disease, Huntington’s disease, chronic fatigue syndrome, and pain syndromes.

В обзоре представлена информация о перспективах использования антидепрессанта агомелатина в неврологической практике. Агомелатин обладает уникальным рецепторным профилем, являясь агонистом мелатониновых рецепторов 1-го и 2-го типов, а также антагонистом серотониновых рецепторов подтипа 2С. Благодаря этому препарат, помимо антидепрессивного действия, оказывает ряд других эффектов, в том числе противоболевой, противоапатический, противоастенический, прокогнитивный, противотревожный и нормализующий сон, которые имеют большое значение при лечении неврологических заболеваний. Представлены клинические и экспериментальные данные, доказывающие высокую эффективность и безопасность агомелатина при кура-ции больных с постинсультными депрессиями, болезнями Паркинсона, Альцгеймера, Пика, Гентингтона, синдромом хронической усталости и болевыми синдромами.

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The authors declare that there are no conflicts of interest present.